Effect of Nutritional Alterations on Protein Synthesis in Transplantable Hepatomas and Host Livers of Rats1
نویسندگان
چکیده
studies, we investigated the effects of: (a) a single feeding of a complete mixture of amino acids on individual amino acids to fasted animals (21 , 24, 27); (b) a single feeding of a purified diet devoid of protein on amino acids (23); (c) force feeding a purified diet devoid of single essential amino acids for 1 to 3 days (16). Under these experimental conditions, hepatic pro tein synthesis was found to be increased in comparison to control groups. On the other hand, a single administration (tube feeding or i.p.) of hypertonic (6%) NaCI solution caused a marked decrease in hepatic protein synthesis (7, 8). Recently, we have become interested in studies dealing with protein metabolism in hepatomas and in host livers of rats bearing transplantable hepatomas (10, 20). In the present investigation, we have undertaken to determine whether nutni tional alterations studied earlier in normal rats would have similar or different effects on hepatomas as well as on host livers of rats bearing transplantable hepatomas either s.c. or intrahepatically.
منابع مشابه
Effect of nutritional alterations on protein synthesis in transplantable hepatomas and host livers of rats.
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